FORTRESS MODE IDH-wildtype · EGFR/PTEN/TERT · Fortress Mode IDH-wildtype / EGFR amp / TERT promoter γ₁ = 14.134725141734693 · GBM · IDH1 · EGFR · TERT · TME · BBB penetrati RASENGAN CANCER BOARD NEURO
GLIOBLASTOMA · GBM
Driver
IDH-wildtype / EGFR amp / TERT promoter
Coverage
~3.2/100k · Median survival 15mo
Confidence
SORRY
Open Sorries
⚠ S001: BBB drug delivery
⚠ S003: TME immunosuppression
⚠ S006: CAR-T P-45 exhaustion
HYPOTHESIS
D2-HG axis: IDH-mut → ivosidenib. IDH-wt → EGFR+CAR-T combo. 5/6 routes closed.
⚠ OPEN: IDH-wildtype simultaneous BBB+CAR-T — S006-wt
3Sorries
γ₁14.134725141734693
CATAN CANCER · BRAIN-GLIOBLASTOMA